Many early-onset colon cancers are caused by genetic mutations passed through families

COLUMBUS, Ohio — One in every six colorectal cancer patients (16 percent) diagnosed under age 50 has at least one inherited genetic mutation that increases his or her cancer risk and many of these mutations could go undetected with the current screening approach, according to initial data from a statewide colorectal cancer screening study conducted at The Ohio State University ...

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Innovating fine needle aspiration for diagnosing autoimmune pancreatitis

Autoimmune pancreatitis (AIP) can closely resemble pancreatic cancer, but these two diseases require distinctly different courses of treatment. A new study suggests that an endoscopic procedure using a larger-gauge needle may offer a solution for making this important differential diagnosis. The study, “Diagnosis of autoimmune pancreatitis by EUS-guided FNA using a 22-gauge needle: a prospective multicenter study,” is published in ...

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Gut cells are gatekeepers of infectious brain diseases, study finds

Fresh insights into infectious brain conditions help to explain why some people – and animals – are more at risk than others. The study reveals how prion diseases – which include variant Creutzfeldt-Jakob disease (vCJD) in people and bovine spongiform encephalopathy (BSE) in cows – can infect the gut if contaminated meat has been eaten. Specialised cells called M cells ...

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Mystery molecule is a key to inhibiting colon cancer

Immunologists at St. Jude Children’s Research Hospital have discovered that a protein called NLRC3 plays a central role in inhibiting colon cells from becoming cancerous. The study, led by Thirumala-Devi Kanneganti, Ph.D., a member of the St. Jude Department of Immunology, appears online today in the journal Nature. Researchers found that deleting the protective NLRC3 protein exacerbates colon cancer development. They ...

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Newly discovered bacteria-binding protein in the intestine

Deficiency in a certain protein in the gastrointestinal tract has been shown to lead to both inflammation and abdominal fat accumulation in mice. The discovery provides yet another piece of the puzzle of how humans are affected — or not — by the large quantities of intestinal bacteria we carry with us. In the study from Sahlgrenska Academy, researchers have ...

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