Blocking two molecular pathways that send signals inside cancer cells could stave off esophageal adenocarcinoma (EAC), the most common esophageal malignancy in the United States, according to new research out of Case Western Reserve University School of Medicine. Researchers identified the pathways using advanced computational and genetic analyses of tumor biopsies from EAC patients. They found 80 percent of tumors ...

Cancer of the esophagus claims more than 400,000 lives around the world each year. With no efficient, reliable method of screening for the disease, by the time symptoms become apparent, it’s often too late to save the patient. A Johns Hopkins researcher who has devoted his career to the detection and prevention of esophageal cancer today published a paper in ...

Evolution describes how all living forms cope with challenges in their environment, as they struggle to persevere against formidable odds. Mutation and selective pressure — cornerstones of Darwin’s theory — are the means by which organisms gain an advantageous foothold or pass into oblivion. In a new study, researchers at ASU’s Biodesign Institute led an international team to explore how ...

Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett’s esophagus that offers promise for preventing deaths from esophageal adenocarcinoma. Barrett’s esophagus (BE) is the precursor lesion of esophageal adenocarcinoma (EAC), a highly lethal cancer with more than 80 percent mortality at five years. ...