Tag Archives: News

Gastrointestinal hormone measurably improved symptoms of non-alcoholic fatty liver disease

Through a randomized, double-blind, placebo-controlled phase II clinical trial, researchers at University of California San Diego School of Medicine report that small doses of NGM282, a non-tumorigenic variant of an endocrine gastrointestinal hormone, can significantly and rapidly decrease liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The findings, they say, represent an important ...

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Study tracks evolutionary transition to destructive cancer

Evolution describes how all living forms cope with challenges in their environment, as they struggle to persevere against formidable odds. Mutation and selective pressure — cornerstones of Darwin’s theory — are the means by which organisms gain an advantageous foothold or pass into oblivion. In a new study, researchers at ASU’s Biodesign Institute led an international team to explore how ...

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The enemy within: Gut bacteria drive autoimmune disease

Bacteria found in the small intestines of mice and humans can travel to other organs and trigger an autoimmune response, according to a new Yale study. The researchers also found that the autoimmune reaction can be suppressed with an antibiotic or vaccine designed to target the bacteria, they said. The findings, published in Science, suggest promising new approaches for treating ...

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No progress seen in reducing antibiotics among outpatients

Despite public health campaigns aimed at reducing unnecessary prescriptions for antibiotics, the drugs continue to be prescribed at startlingly high rates in outpatient settings such as clinics and physician offices, according to a new study at Washington University School of Medicine in St. Louis. The researchers analyzed de-identified data from Express Scripts Holding Co., which manages drug benefits for employers, ...

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True to type: From human biopsy to complex gut physiology on a chip

The small intestine is the main site where we digest and absorb nutrients and minerals from food, and it is also a place where many intestinal infections occur and digestive and inflammatory disorders manifest themselves. To better understand the intestine in its normal and pathological states, researchers have created “organoids” by isolating intestinal stem cells from human biopsy samples. These ...

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