Findings could lead to additional targeted treatments for more patients In recent years, researchers have identified specific gene mutations linked to gastrointestinal stromal tumors (GIST), which primarily occur in the stomach or small intestine, with 5,000 to 6,000 new cases per year in the United States. But 10 to 15 percent of adult GIST cases and most pediatric cases lack ...

COLUMBUS, Ohio — One in every six colorectal cancer patients (16 percent) diagnosed under age 50 has at least one inherited genetic mutation that increases his or her cancer risk and many of these mutations could go undetected with the current screening approach, according to initial data from a statewide colorectal cancer screening study conducted at The Ohio State University ...

Scientists have identified chemical changes in the DNA of patients with inflammatory bowel diseases that could improve screening for the conditions. The DNA changes can be detected in blood samples, paving the way for simple tests to aid diagnosis. Researchers say their findings shed light on how the diseases develop and could reveal new approaches to treatments. Inflammatory bowel diseases ...

An international collaboration between the University of Oxford and other European institutions has uncovered a correlation between a rare mutation in bowel cancers and a better prognosis, raising the possibility that patients with such tumours may not require chemotherapy after surgery. The study focused on colorectal (bowel) cancers and examined the presence of mutations in a gene that is essential ...