Tag Archives: Cancer

Gene mutations among young patients with colorectal cancer

While many patients with colorectal are diagnosed when they are older than 50, about 10 percent of patients are diagnosed at younger ages. So what is the frequency of cancer susceptibility gene mutations among patients with colorectal cancer who are diagnosed younger than 50? A new study published online by JAMA Oncology by Heather Hampel, M.S., C.G.C., of the Ohio State University ...

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New gene fusions and mutations linked to gastrointestinal stromal tumors

Findings could lead to additional targeted treatments for more patients In recent years, researchers have identified specific gene mutations linked to gastrointestinal stromal tumors (GIST), which primarily occur in the stomach or small intestine, with 5,000 to 6,000 new cases per year in the United States. But 10 to 15 percent of adult GIST cases and most pediatric cases lack ...

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Many early-onset colon cancers are caused by genetic mutations passed through families

COLUMBUS, Ohio — One in every six colorectal cancer patients (16 percent) diagnosed under age 50 has at least one inherited genetic mutation that increases his or her cancer risk and many of these mutations could go undetected with the current screening approach, according to initial data from a statewide colorectal cancer screening study conducted at The Ohio State University ...

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Mystery molecule is a key to inhibiting colon cancer

Immunologists at St. Jude Children’s Research Hospital have discovered that a protein called NLRC3 plays a central role in inhibiting colon cells from becoming cancerous. The study, led by Thirumala-Devi Kanneganti, Ph.D., a member of the St. Jude Department of Immunology, appears online today in the journal Nature. Researchers found that deleting the protective NLRC3 protein exacerbates colon cancer development. They ...

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Study says CT use OK for some colon cancers, yet challenging for lymph node involvement

CT has good sensitivity for the detection of colon cancers with tumors that have spread beyond the bowel wall, however, it remains a challenge in detecting nodal involvement, which could have considerable consequences given the increasing interest in neoadjuvant treatment for colon cancer. This finding was published in the November 2016 issue of the American Journal of Roentgenology (AJR) in an article ...

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