Study: Nitrate in drinking water increases the risk of colorectal cancer

A new study from Aarhus University now shows that there is an increased risk of colon and rectal cancer in connection with nitrate in drinking water. Also at concentrations far below the current drinking water standard. The highest nitrate concentrations are mainly seen in small private water supplies. Nitrate in groundwater and drinking water, which primarily comes from fertilisers used ...

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Gut microbes protect against sepsis: Mouse study

Sepsis occurs when the body’s response to the spread of bacteria or toxins to the bloodstream damages tissues and organs. The fight against sepsis could get a helping hand from a surprising source: gut bacteria. Researchers reporting February 22 in the journal Cell Host & Microbe found that giving mice particular microbes increased blood levels of immunoglobulin A (IgA) antibodies, ...

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Low-calorie diet enhances intestinal regeneration after injury

Dramatic calorie restriction, diets reduced by 40 percent of a normal calorie total, have long been known to extend health span, the duration of disease-free aging, in animal studies, and even to extend life span in most animal species examined. Further research has shown that animals fed restricted-calorie diets are also better able to regenerate numerous tissues after injury. A ...

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Researchers develop swallowable test to detect pre-cancerous Barrett’s esophagus

Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett’s esophagus that offers promise for preventing deaths from esophageal adenocarcinoma. Barrett’s esophagus (BE) is the precursor lesion of esophageal adenocarcinoma (EAC), a highly lethal cancer with more than 80 percent mortality at five years. ...

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Scientists produce human intestinal lining that re-creates living tissue inside organ-chip

Investigators have demonstrated how cells of a human intestinal lining created outside an individual’s body mirror living tissue when placed inside microengineered Intestine-Chips, opening the door to personalized testing of drug treatments. The findings have the potential to change how patients are treated for debilitating, inflammatory gastrointestinal diseases with a genetic component, such as Crohn’s disease, ulcerative colitis and irritable ...

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