Molecule plays dual role in bowel health and disease

A molecule that controls intestinal cell growth plays a dual role maintaining gut health and promoting diseases such as cancer, says a study in eLife. The discovery in mice sheds light on the intricate mechanisms that control cell turnover in the gut, and provides a potential new therapeutic target for intestinal diseases such as bowel cancer. The lining of our ...

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‘Poop pill’ capsule research paves the way for simpler C. difficile treatment

An Alberta-led clinical trial has shown Fecal Microbiota Transplant (FMT) is effective in treating clostridium difficile (C. difficile) infections whether delivered by colonoscopy or by swallowing capsules. The finding, published in the Journal of the American Medical Association, could revolutionize and broaden the use of FMT, which restores the healthy balance of bacteria living in the intestine by transferring a ...

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Racial disparities persist in the survival of patients with ovarian, colon, and breast cancer

Three new articles present trends in survival for patients with ovarian, colon, and breast cancer in the United States by race and stage. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings reveal large, consistent, and persistent racial disparities in survival. For the analyses, a team led by investigators at the Centers for Disease ...

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Finding a less poopy solution for fecal transplant regulation

As fecal matter transplants (FMTs) continue to be more widely adopted, it is critical to have an appropriate regulatory framework in place, authors of this Policy Forum emphasize. They go on to outline key areas for improvement, compared to current regulatory approaches. The transfer of stool from one healthy donor to a recipient for re­current Clostridium difficile infection (CDI) is ...

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New protocol leads to significant drop in prescription narcotic use among colorectal surgery patients

A quality improvement initiative has led to a significant drop in narcotic pain medications prescribed to patients who undergo colorectal surgery at UF Health Shands Hospital in Gainesville, Florida. “Fewer patients are receiving oral narcotics during their hospital stay. More importantly, we are discharging even fewer patients with prescriptions for narcotic pain medication. Often, patients become addicted after taking legally ...

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