Study to compare the effectiveness of biologic or small molecule therapies in IBD receives funding

Crohn’s disease (CD) and ulcerative colitis (UC), collectively referred to as inflammatory bowel diseases (IBD), which may affect as many as 3 million Americans, cost over $6 billion annually, and cause substantial patient morbidity, missed work and school, and diminished quality of life. Currently, anti-TNF therapy is considered first line treatment for moderate-to-severe IBD. However, up to 80 percent of ...

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Penn study reveals secrets of ‘hot’ and ‘cold’ pancreatic cancer tumors

So-called “hot” tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to “cold” tumors with fewer T cells, but a clear demonstration of why has eluded cancer biologists–until now. A team from Penn Medicine’s Abramson Cancer Center (ACC) discovered that whether a tumor is hot or cold is determined by information embedded in the ...

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Timing is key for bacteria surviving antibiotics

For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment. When antibiotics hit a population of bacteria, often a small fraction of “persister” cells survive to pose a ...

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Possible link between IBD and Parkinson’s might allow doctors to slow down neurological condition

Doctors may be able to modify or slow down the progress of the neurological condition Parkinson’s disease in the future by spotting signs of it in patients with inflammatory bowel disease (IBD), suggests a study published in the journal Gut. Danish researchers found patients with IBD appeared to have a 22 percent greater risk of developing Parkinson’s disease in a study ...

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Antifungal drug eliminates sleeping bowel cancer cells in mice

Researchers at the Cancer Research UK Cambridge Institute have shown in laboratory studies in mice, that itraconazole effectively halts the growth and progression of certain types of bowel cancer. The next step will be to see if this holds true in patients with the disease. “One of the biggest challenges in treating any cancer is the diversity of different cells within the ...

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