First 3-D map of cell-building protein linked to cancer

Walter and Eliza Hall Institute researchers have revealed for the first time the three-dimensional molecular ‘map’ of a protein that has been pinpointed as a driver of many types of cancers. The unprecedented view of the protein doublecortin kinase like domain 1 (DCLK1) could provide clues to how it contributes to cancer formation and progression. DCLK1 is a protein that ...

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‘Born to be bad’ or ‘born to be benign’ — testing cells for esophageal cancer risk

Genetically analysing lesions in the food pipe could provide an early and accurate test for oesophageal cancer, according to research led by Queen Mary University of London (QMUL), Academic Medical Center in Amsterdam and Arizona State University. The study, published in Nature Communications, shows that some cells that are ‘born to be bad’ could be identified early on, preventing the need ...

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Ginger-derived nanoparticles may be good medicine for Crohn’s disease and ulcerative colitis,

A recent study by researchers at the Atlanta VA took them to a not-so-likely destination: local farmers markets. They went in search of fresh ginger root. Back at the lab, the scientists turned the ginger into what they are calling GDNPs, or ginger-derived nanoparticles. The process started simply enough, with your basic kitchen blender. But then it involved super-high-speed centrifuging ...

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Rare mutations in bowel cancer may identify patients with a better prognosis

An international collaboration between the University of Oxford and other European institutions has uncovered a correlation between a rare mutation in bowel cancers and a better prognosis, raising the possibility that patients with such tumours may not require chemotherapy after surgery. The study focused on colorectal (bowel) cancers and examined the presence of mutations in a gene that is essential ...

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VA and Regenstrief researchers working to identify risk factors for colon cancer under 50

While the incidence of colon cancer has been declining in individuals 50 years old and older in the United States, it is steadily rising in those under age 50. With funding from the U.S. Department of Veterans Affairs, Thomas F. Imperiale, M.D., a VA and Regenstrief Institute clinician-researcher, is developing and validating a model to predict risk for colon cancer ...

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