Gut cells are gatekeepers of infectious brain diseases, study finds

Fresh insights into infectious brain conditions help to explain why some people – and animals – are more at risk than others. The study reveals how prion diseases – which include variant Creutzfeldt-Jakob disease (vCJD) in people and bovine spongiform encephalopathy (BSE) in cows – can infect the gut if contaminated meat has been eaten. Specialised cells called M cells ...

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Mystery molecule is a key to inhibiting colon cancer

Immunologists at St. Jude Children’s Research Hospital have discovered that a protein called NLRC3 plays a central role in inhibiting colon cells from becoming cancerous. The study, led by Thirumala-Devi Kanneganti, Ph.D., a member of the St. Jude Department of Immunology, appears online today in the journal Nature. Researchers found that deleting the protective NLRC3 protein exacerbates colon cancer development. They ...

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Newly discovered bacteria-binding protein in the intestine

Deficiency in a certain protein in the gastrointestinal tract has been shown to lead to both inflammation and abdominal fat accumulation in mice. The discovery provides yet another piece of the puzzle of how humans are affected — or not — by the large quantities of intestinal bacteria we carry with us. In the study from Sahlgrenska Academy, researchers have ...

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Review examines rates and predictors of recurrence following surgery for Crohn’s disease

Some patients with Crohn’s disease, a chronic inflammatory disease that affects the lining of the digestive tract, require surgery to remove part or all of the large intestine; however, surgery does not cure the condition and many patients relapse after surgery. A new review and analysis of published studies provides insights on the rates of relapse and predictors of relapse ...

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Cedars-Sinai receives $10 million for pioneering studies of debilitating digestive tract disease

NIH grant funds research of complex genetic factors in inflammatory bowel disease Cedars-Sinai investigators in gastroenterology have been awarded $10 million by the National Institutes of Health to conclude a groundbreaking, decades-long investigation of the genetic and immunological causes of inflammatory bowel disease (IBD). “This is the longest IBD study of its kind funded by the NIH and the first to ...

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