Pancreatic Cancer

Fungal invasion of pancreas creates cancer risk

Certain fungi move from the gut to the pancreas, expand their population more than a thousand-fold, and encourage pancreatic cancer growth, a new study finds. Published online in Nature, the study is the first to offer strong evidence that the mycobiome—the local mix of fungal species in the pancreas—can trigger changes that turn normal cells into pancreatic ductal adenocarcinoma (PDA). This form of ...

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Many patients with pancreatic cancer miss out on treatment that may extend survival

Despite potential for prolonging survival with treatment, one-third of patients with metastatic pancreatic cancer do not see a medical oncologist, and even more do not receive cancer-directed treatment, found new research published in CMAJ (Canadian Medical Association Journal). Pancreatic cancer has a high death rate and is often diagnosed in advanced stages. “The data suggest that there are many missed opportunities for important ...

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Tongue microbiome could help identify patients with early-stage pancreatic cancer

CREDIT: OLEG MAGNI FROM PEXELS

Differences in the abundance of certain bacteria living on the tongue can distinguish patients with early pancreatic cancers from healthy individuals, according to results from a new study published in the Journal of Oral Microbiology. Although disruptions to the microbiome – the population of microorganisms that live in and on our bodies – have already been identified in pancreatic cancer patients ...

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Penn study reveals secrets of ‘hot’ and ‘cold’ pancreatic cancer tumors

So-called “hot” tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to “cold” tumors with fewer T cells, but a clear demonstration of why has eluded cancer biologists–until now. A team from Penn Medicine’s Abramson Cancer Center (ACC) discovered that whether a tumor is hot or cold is determined by information embedded in the ...

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